Positions Available

Director of the Health Sciences and Technology Division, Massachusetts Institute of Technology

The Massachusetts Institute of Technology (MIT) is seeking a dynamic, innovative leader to direct the Harvard-MIT Division of Health Sciences and Technology. We are looking for a distinguished researcher in a field of science, engineering or medicine with demonstrated accomplishments in a major leadership role. The Director is responsible for overall Division leadership and administration, and works closely with the HST Director counterpart at Harvard Medical School (HMS). The MIT and HMS Directors of HST jointly oversee a longstanding, multi-institutional program that includes MIT, HMS, Harvard University, several Boston area teaching hospitals, and a number of research centers that, collectively, form a unique collaboration that integrates science, medicine and engineering to solve problems in human health.

HST currently trains some 400 graduate students in the fields of science, medicine, engineering and management. A hallmark of the HST educational process is that innovation and entrepreneurship are encouraged through side-by-side training of outstanding students with diverse backgrounds for careers in the biomedical sciences and engineering. HST offers the following PhD programs based at MIT: Medical Engineering and Medical Physics (MEMP), Speech and Hearing Bioscience and Technology, and Radiological Sciences Joint Program. The MEMP PhD offers specialized training programs in Bioinformatics and Integrative Genomics, Neuroimaging and Bioastronautics. HST Master's programs include the Master of Engineering in Biomedical Engineering and the Biomedical Enterprise Program - along with Master's degree options in Biomedical Informatics and Clinical Investigator Training. HST also offers MD and MD/PhD programs based at HMS. For additional information about HST's research and educational programs, please visit http://hst.mit.edu/.

The past decade has seen significant development of HST's faculty, including a new structure that includes 65 faculty and 180 affiliated faculty. Consistent with HST's multi-institutional structure, these faculty have appointments at MIT, HMS and/or the Harvard-affiliated teaching hospitals. Of the 65 faculty, 12 have primary appointments in HST at MIT; the others have joint/secondary appointments in HST at MIT or HMS. The faculty pursue a wide range of research interests, with expected new hires in areas including, but not limited to, bioinformatics, computational biology, biomedical imaging, or regenerative biomedical technologies. The new director will shape the continuing development and renewal of HST's faculty.

To be considered for this position, please submit a letter of interest, a curriculum vitae and a vision statement describing how HST, as an inter-institutional program involving local teaching hospitals, can advance MIT's strengths in engineering and biology toward medical applications.

Massachusetts Institute of Technology is an affirmative action, equal opportunity employer. Women and under represented minority candidates are strongly encouraged to apply.

Junior Faculty Position

The Massachusetts Institute of Technology (MIT) seeks candidates for a tenure-track faculty position (Assistant or Associate Professor level) offered in the Harvard-MIT Division of Health Sciences and Technology (HST). To assure strong linkages, the candidate will also have a dual appointment in one of the departments within MIT's School of Engineering (SoE).

We seek candidates who have earned a doctorate in the broad field of biomedical engineering. Candidates could come from such fields of particular interest to HST as imaging and biomedical optics, bioinformatics and computational biology, and/or functional and regenerative biomedical technology or related fields. Faculty duties will include teaching undergraduate and graduate students, research, and supervision of theses. We seek candidates who will interact productively with students and faculty in HST and its affiliated departments at both MIT and Harvard, thereby fostering interdisciplinary research and teaching.

Candidates must register with the HST search website at https://hst-faculty-search.mit.edu/hst-soe.adp. All application materials should be submitted electronically to the website. (If this is not possible, the application may be sent to the address below.) Candidate applications should include a description of professional interests and goals in both teaching and research. Each application should include a curriculum vitae and the names and addresses of three or more individuals who will provide letters of recommendation. Candidates are expected to ask recommenders to submit their letters directly to MIT on the website, or, if this is not possible, by mailing to the address below. Although applications will be accepted until the position is filled, completed applications will be reviewed starting November 1, 2008.

Junior Faculty Position

The Massachusetts Institute of Technology (MIT) seeks candidates for a tenure-track faculty position (Assistant or Associate Professor level) offered in the Harvard-MIT Division of Health Sciences and Technology (HST). This position carries with it an appointment to the Athinoula A. Martinos chair.

We seek candidates who have earned a doctorate in a field related to biomedical imaging. Candidates could come from such fields as chemistry, physics, biology and/or biological, electrical or biomedical engineering. We are especially interested in applicants working in areas related to PET radio-chemistry, molecular imaging or other associated areas of biomedical imaging.

Faculty duties will include teaching undergraduate and graduate students, research, and supervision of theses. We seek candidates who will interact productively with students and faculty in HST and its affiliated departments at both MIT and Harvard, thereby fostering interdisciplinary research and teaching. Candidates are encouraged to consider a dual appointment in a collaborating MIT department.

In particular, we seek candidates who will contribute to the research and educational efforts of HST's Athinoula A. Martinos Center for Biomedical Imaging at MIT and at the Massachusetts General Hospital in Charlestown, Massachusetts. The Athinoula Martinos Center has state-of-the-art medical imaging facilities including numerous high-field human and animal MRIs, MEG, and optical imaging laboratories across its campuses. Of special note, a new PET and molecular imaging facility, including advanced hybrid PET/MRI cameras and full radiopharmaceutical synthesis and production facilities, is now being planned, and candidates with expertise in these domains are encouraged to apply to provide leadership for this new effort.

Candidates must register with the HST search website at
http://hst-faculty-search.mit.edu. All application materials should be submitted electronically to the website. (If this is not possible, the application may be sent to the address below.) Candidate applications should include a description of professional interests and goals in both teaching and research. Each application should include a curriculum vitae and the names and addresses of three or more individuals who will provide letters of recommendation. Candidates should ask recommenders to submit their letters directly to MIT on the website, or, if this is not possible, by mailing to the address below. Although applications will be accepted until the position is filled, completed applications will be reviewed starting September 15, 2007.

MIT is an equal opportunity/affirmative action employer.

For more information about HST, please visit http://hst.mit.edu/. For more information about the Martinos Center for Biomedical Imaging, please visit: http://www.nmr.mgh.harvard.edu/martinos/flashHome.php/.

Assistant or Associate Professor (Photodynamic Therapy)

The Wellman Center for Photomedicine at Harvard Medical School and the Harvard University-Massachusetts Institute of Technology Division of Health Sciences and Technology (HST) are collaborating in the search for a candidate at either the Assistant or Associate Professor level who will establish new research programs in biomedical optics, focused on the application of photodynamic therapy (PDT) in areas such as (but not limited to) cancer research, infectious diseases, and imaging. The candidate will be expected to promote and foster multidisciplinary research with joint faculties within Wellman, HST, and the larger MGH and Harvard research communities.

The Wellman Center, located on the campus of the Massachusetts General Hospital, will be the primary physical location for this faculty member. The Wellman Center for Photomedicine (WCP) conducts basic and applied research to investigate the use of optical technologies in medicine and biology (http://www.mgh.harvard.edu/wellman); this is where the only first-line clinical application of PDT for treatment of choroidal neovascularization secondary to age-related macular degeneration (Visudyne) was co-developed. Ongoing translational programs at WCP emphasize the development of imaging technologies, tissue optics, and new combination treatments, such as PDT with differentiation and immune therapies, and PDT of disease-specific molecular targets. Active PDT research at WCP focuses on cancer (ovarian, prostate, skin, GI, head & neck), cardiovascular and infectious diseases, immunology, and ophthalmology.

The ideal candidate would combine a record of achievement in scientific research and a demonstrated interest in translational research, with an MD, a PhD, or an MD-PhD. A strong publication record and evidence of ability to obtain independent peer-reviewed funding is expected. Although there is interest in a candidate with a program in cancer biology, applicants in a wide range of research disciplines will be considered as long as there is a commitment to developing PDT research (see additional PDT program information at http://www.dartmouth.edu/~pdt/).

Applicants should submit the following: (i) curriculum vitae, (ii) a statement of teaching interests, (iii) a statement of research interests and goals demonstrating commitment to PDT, (iv) brief ideas of potential collaborative possibilities with WCP and HST faculty (http://hst.mit.edu), (v) plans for future funding, and (vi) reprints of selected recent publications. Applicants also need to make arrangements to have three letters of recommendation sent on their behalf directly to the Search Committee Chair. Although applications will be accepted until the position is filled, complete applications (with at least three references in hand) will be reviewed beginning May 30, 2008.

Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology are Equal Opportunity Employers. Women and minorities are encouraged to apply.

Research Engineer

DESCRIPTION: Research Engineer, HST Laboratory for Computational Physiology, to work on the development of a major new research database of physiologic and clinical data from intensive care patients that will support the design and evaluation of advanced patient monitoring algorithms, as well as retrospective clinical studies. The computational environment consists of 25 servers for storage and signal processing of around 50 TB of data, together with off-site mirrors. We seek a highly qualified, creative software engineer to aid our research group in administering and developing the ongoing collection, analysis, documentation and distribution of the database. The individual will also be expected to contribute to the design and implementation of innovative systems that will permit the clinical evaluation of advanced monitoring algorithms in our collaborating hospital. Duties will include system administration, database management, network management and archiving tasks in Linux environments, documentation, plus GUI interface maintenance and development. Opportunities for individual original research are possible.

QUALIFICATIONS: A master's degree in electrical engineering, computer science, biomedical engineering (or related disciplines), or a bachelor's degree plus relevant experience; competence and experience in a useful subset of the following: Linux, C/C++, Java, Bash, Perl, SQL, Oracle, PostgreSQL, MATLAB, Windows, and digital signal processing; experience in biomedical engineering desirable but not required. Strong interpersonal and communication skills and fluency in English are essential. Experience in administering and designing databases and networks, and experience in GUI development for non-technical users are highly desirable.

Research Engineer

DESCRIPTION: Research Engineer, HST Laboratory for Computational Physiology, to design, implement, and test original software and modifications of existing software for digital signal processing and analysis of large biomedical database, and write clear user-level documentation. The major focus of our work is the support and expansion of PhysioNet (www.physionet.org), a large open source archive of physiologic signals and signal processing software. This position requires excellent programming and technical writing skills. Duties also will include system administration, database management, network management and archiving tasks in Linux environments. The position affords the opportunity for a highly motivated individual to achieve professional recognition by creating innovative open-source (free) software.

Qualifications/Requirements: A master's degree in electrical engineering, computer science, biomedical engineering (or similar field), or bachelor's degree plus relevant experience. Solid C programming and shell scripting skills, and familiarity with the POSIX (Linux/Mac OS X/Unix) environment are required. Experience and competence is expected in a useful subset of the following: Cygwin (POSIX for Windows), Django, Java (including GUI design), Perl, Python, MATLAB, R, relational databases, and web design. Strong interpersonal and communication skills and fluency in English are essential.

Postdoctoral Associate

MIT; Outstanding candidate sought to develop tissue engineering research projects significant to human healthcare and NASA's new mission. Research will involve structural, functional and molecular level studies of cell-biomaterial constructs using in vitro (bioreactor) and in vivo (implant) models.

Postdoctoral Associate

A post-doctoral position is available in the laboratory of Dr. Sangeeta Bhatia, MD, PhD, to study the role of microenvironmental signals in embryonic stem (ES) cell growth and differentiation.

Research in the laboratory is focused on the applications of micro- and nanotechnology to tissue repair and regeneration. In particular, we have developed a number of microfabrication tools that enable systematic and combinatorial analysis of environmental interactions (soluble, cell-cell, cell-extracellular matrix) critical for cellular functions and fate determinations. The primary focus of this post-doctoral position will be to utilize microtechnology approaches to identify and examine important inductive cellular interactions for directed ES cell differentiation in vitro. These efforts will provide key information towards the advancement of ES cell differentiation protocols and a more thorough understanding of the role of cell-cell interactions in stem cell functions and embryonic development.

Minimum requirements for this position include a PhD and/or MD. Successful candidate will have a strong background in developmental and stem cell biology with an interest in tissue engineering approaches and high-throughput applications. Candidates possessing strong engineering backgrounds with substantial experience in biological systems will also be considered. Prior experience with stem cell culture, microscopy, flow cytometry, and molecular biology is essential

Postdoctoral Position

The interactions between transcription factors and their DNA binding sites are essential to the regulation of genetic networks within cells. Using a DNA microarray technology that we developed, we have analyzed the DNA binding specificities of not only individual proteins, but also selected pools of proteins, as well as entire libraries of proteins. We are currently using a version of this technology that permits measurement of the direct binding of transcription factor DNA binding domains to microarrays spotted with coding and intergenic region DNAs. This allows us to identify genomic locations of transcription factors' DNA binding sites, and thus what genes they might regulate. These data can also be used in a predictive manner to search related genomes for locations of these regulatory elements. Such data provide a highly informative connection between mRNA expression analysis, proteomics, and structural genomics.

Postdoctoral Position

Postdoctoral Scientist (Harvard Medical School), MGH-NMR Center, Department of Radiology, Massachusetts General Hospital.

Applications are invited for a postdoctoral training position at the Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging at MGH, starting September 01, 2004. This position is part of an NIH sponsored training program and is therefore restricted to US citizens and/or permanent residents. The purpose of this two-year program is to provide an opportunity for highly qualified postdoctoral scientists to begin their career in an outstanding multidisciplinary imaging environment under the tutelage of a senior faculty mentor. The program offers both education and training in the principles and applications of optical and MR-imaging techniques to address important tumor biology questions. Candidates must have an MD, MD/PhD or PhD degree in biophysics, biomedical engineering or related fields and should have documented experience in cancer research as well as a strong interest in optical, MR- or PET imaging of tumor growth processes. Computational (C, C++ or Java) and mathematical modeling skills are required and preference will be given to candidates with demonstrated interdisciplinary strengths in the area of systems biology. The successful candidate will combine cutting edge in vitro and in vivo cancer imaging research with innovative computational biology approaches.

Massachusetts General Hospital is an equal opportunity employer and women and minorities are encouraged to apply.

Postdoctoral Position

A POSTDOCTORAL POSITION is available in the Division of Genetics at Brigham & Women?s Hospital and Harvard Medical School, for a highly motivated individual interested in transcriptional regulation, functional genomics and proteomics. This research project will focus on interactions between mammalian transcription factors and their DNA binding sites, using protein binding microarrays (Nature Genetics. 2004 Dec; 36(12):1331-1339). The work will require a range of techniques including but not limited to: PCR; cloning, expression and purification of fusion proteins; microarray experiments; microarray data analysis. This position offers the opportunity to work in a highly collaborative environment.
Applicants should have a recent PhD Prior experience in protein expression and purification is required. Strong quantitative skills and prior programming experience are recommended, as some bioinformatics programming will be required in this research project. Solid command of spoken and written English is required.

We offer competitive salaries and benefits, and a highly interactive academic environment within the Harvard Medical School community.

Postdoctoral Research Positions

Brigham and Women's Hospital
Harvard Medical School
Harvard-MIT Division of Health Sciences and Technology

Postdoctoral positions are available in the Cohen laboratory in the areas of cholesterol/lipid metabolism and obesity.

A position is available to study new mouse models of obesity and fatty liver disease. The candidate should have a PhD and/or MD or DVM. Experience in the creation and/or utilization of knockout and transgenic mouse models is desirable, as is thorough familiarity with molecular biological and routine biochemical/cell culture techniques.

A position is also available for the study of the function and structure of proteins that regulate lipid metabolism in the liver and adipose tissue. The candidate should have a PhD and/or MD or DVM. A strong background in the protein biochemistry, as well as the cloning, expression and purification of recombinant proteins is desirable.

UROP Opportunity

Project Title: Medical Image Computing Software: Open Source Engineer

Project Description: We need someone to work with advanced CT and MRI 3D image data and cross platform open source software systems (3D Slicer, VTK, ITK and related tools). Responsibilities include testing functionality of rapidly evolving software as new features are added and troubleshooting of extensive curriculum of image analysis tutorials. This UROP will work with training materials aimed at both doctors and programmers. All software, data, and training materials for this project are open source. The ideal candidate will work well independently, but communicate effectively with a dynamic, distributed development and user community via email, wiki, and face to face meetings.

Prerequisites: Qualifications: experience with Windows, Mac, and Linux software installation, compilation, and operation. Programming experience on at least one platform required. Interest in biology and medical imaging required. Prior 3D graphics or image analysis experience preferred. For the academic year, a commitment of at least 10 hours per week in the lab is required. The stipend offered for this position will exceed the UROP minimum; the exact level will depend on relevant prior laboratory training and experience. Candidates who can continue with us as UROPs into IAP and the 2009 spring semester and summer are preferred.

Project websites:
http://www.na-mic.org
http:// www.slicer.org
http://www.vtk.org
http://www.itk.org
http:// www.cmake.org